• − Although a small increase in N-cadherin is seen during normal differentiation (1.5–2-fold at 48 vs. 24 h), this is significantly less than that seen with ectopic α5 integrin expression. These conditions include specific growth factors containing media and extracellular matrix … − Van Der Flier, S. Van Delft et al., “Induction of cell scattering by expression of, E. Hintermann, N. Yang, D. O'Sullivan, J. M. G. Higgins, and V. Quaranta, “Integrin, K. J. Hodivala and F. M. Watt, “Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation,”, A. Huttenlocher, M. Lakonishok, M. Kinder et al., “Integrin and cadherin synergy regulates contact inhibition of migration and motile activity,”, Q. Lu, M. Paredes, J. Zhang, and K. S. Kosik, “Basal extracellular signal-regulated kinase activity modulates cell-cell and cell-matrix interactions,”, M. Marsden and D. W. 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Furthermore, there is evidence that growth factor receptors mediate signaling through a subset of signaling endosomes termed redoxosomes (redox-active endosomes), which are uniquely equipped with redox-processing proteins capable of transmitting ROS signals from the endosome interior to redox-sensitive effectors on the endosomal surface, thereby controlling redox-dependent effector functions through the spatial and temporal regulation of ROS as second messengers [117]. from NADPH oxidase, which in turn inhibits LMW-PTP. Press question mark to learn the rest of the keyboard shortcuts. , which are generated constitutively, as common by-products of oxidative metabolism, or in response to the activation of several oxidative enzyme complexes [52–55]. Review articles are excluded from this waiver policy. O O This work was supported by grants to S. F. Retta from the Fondazione Telethon (grant N° GGP06222) and the Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR - PRIN 2008). 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