Br J Nutr 2004;91(6):943-950. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. These are black colored berries which leave a purple color on the tongue when eaten. Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment. Alt Ther 2001;7(6):58-67. The 24.4% decrease in activity of beta-glucuronidase, a biomarker for risk of colon cancer and a microbial enzyme known to increase the formation of carcinogens in the bowel, was also statistically significant compared with baseline (P<0.05).Molan 2014, The anti-inflammatory effects of black currant seed oil and prodelphinidins from the leaves have been studied in animal and in vitro settings.Barre 2001, Garbacki 2002, Garbacki 2004 In cultured macrophages, black currant juice exerted anti-inflammatory effects, as evidenced by reduced levels of tissue necrosis factor alpha, IL-1beta, and inducible nitric oxide synthase.Huebbe 2012, A Cochrane review of trial data suggests some benefit from gamma-linolenic acid in rheumatoid arthritis, despite the relatively poor quality of the individual studies.Little 2001 A trend toward reduction of morning stiffness and joint tenderness, as well as pain relief, was shown. Capsules, although more expensive, might be your answer. Black Currant Seed Oil is Packed with Antioxidants. Dalgård C, Nielsen F, Morrow JD, et al. In a small, double-blind, randomized, placebo-controlled study of untrained healthy young adults 18 to 40 years of age (N=16), consumption of black currant nectar (32 oz/day; containing 200 g/day of fruit) for 8 days was investigated for its effects on muscle damage and inflammation following a session of high-intensity leg squats. View abstract. Menendez JA, Colomer R, Lupu R. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-Linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. Avoid topical oil preparations. [Polyphenolic antioxidants in fruit juice. Dosing considerations for Black Currant. Prostaglandins Leukot.Essent.Fatty Acids 1995;53(6):401-404. View abstract. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. For black currant oil supplements, an even higher dosage is used to obtain the equivalent amount of GLA. Traitler H, Winter H, Richli U, Ingenbleek Y. CONDITIONS OF USE AND IMPORTANT INFORMATION: Apparently, not everything that’s free is good for … Keeps Skin Looking Youthful. *Black currant oil … Microbial enzyme activity that likely reflected increased activity of lactobacilli increased significantly at 2 weeks and remained significantly increased for 2 weeks after discontinuation of black currant extract powder (P<0.05). In a study small study of healthy subjects (N=30) to determine whether black currant used as a prebiotic positively modifies colonic microbiota, administration of black currant extract powder (Cassis Anthomix 30) 672 mg/day for 2 weeks significantly improved gut microbiota. With regards to dosage, start off with one to two capsules a day for three days, increasing your dosage to three capsules a day. It is … View abstract. Last updated on Apr 21, 2020. Black Currant Dosage: Take 500 milligrams twice a day for at least two months. Int J Cancer 2000;85:643-8. J.Agric.Food Chem. Medically reviewed by Drugs.com. Know what's in your product with Connoils. EPOGAM Capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. View abstract. An inverse relationship between vitamin C content and cancer cell proliferation was noted, with berry extracts with high vitamin C content inhibiting cancer cells to a greater extent.Olsson 2004, Also in vitro, black currant effectively inhibited the proliferation of various cancer cell lines, including Caco-2, MCF-7, AGS, and MDA-MB-231 cell lines (mammary gland, stomach, and colorectal adenocarcinomas).Boivin 2007 In another in vitro study, black currant 20 mg/mL inhibited growth (20% reduction) of HT-29 colon cancer cells; specifically, expression of p21WAF1, a cell proliferation inhibitor, increased 2.7-fold with black currant at a concentration of 40 mg/mL.Wu 2007, An aqueous extract of black currant fruit skin exerted a cytotoxic effect against HepG2 human liver cancer cells.Bishayee 2010, Research reveals no clinical data regarding black currant use in cancer. The oil reduces treat the pain and swelling of joints caused by arthritis. (3, 4) Even hormonal imbalances affecting the thyroid and menopause may be balanced out by taking black currant seed oil in the right dosage … This information relates to an herbal, vitamin, mineral or other dietary supplement. Black Currant Oil Benefits and Uses for Skin. https://www.healthline.com/health/health-benefits-black-currant How Long Does Coronavirus Live On Surfaces? Antioxidant capacity closely correlates to total phenolic contentEhala 2005, Nakajima 2004; however, individual phenolic compounds may contribute to differing extents.Breinholt 2003, Joseph 2004, Matsumoto 2002, Viljanen 2004, Wu 2004 It has been suggested that the lipophilic antioxidant capacity is low, while the hydrophilic antioxidant capacity of phenolic compounds is higher.Wu 2004 Vitamin C content is the major contributor to the antioxidant capacity of black currant.Nielsen 2003, Anthocyanins and flavonoids in black currant berries and juice have low bioavailability and are considered poor sources of antioxidants.Erlund 2003, Mülleder 2002, Young 1999, A correlation between vitamin C content and in vitro inhibition of cancer cell proliferation was found when examining antioxidant capacity.Olsson 2004, Black currant juice increased radical scavenging capacity in cultured macrophages.Huebbe 2012, In rats intoxicated with ethanol, black currant protected lipids and proteins against oxidation, possibly because of its ability to scavenge free radicals and chelate metal ions.Szachowicz-Petelska 2012, In a study of pigs, vitamin E appeared to be a more efficient antioxidant than black currant juice.Salobir 2010, No differences in antioxidant activity and biochemical markers were found in 22 elderly patients participating in a 2-week study of berry-enriched desserts.Carmen Ramirez-Tortosa 2004 No difference was found in oxidative DNA damage in a 3-week trial of 60 healthy, adequately nourished adults receiving large amounts of berries in their diet.Møller 2004 Similarly, no difference in antioxidant activity was observed between placebo and black currant anthocyanins (50 mg/day for 2 years) administered to patients with open-angle glaucoma.Yoshida 2013 In a substudy of a larger double-blind, randomized, placebo-controlled trial, black currant dietary antioxidants did not provide any photoprotection at either low or high concentrations (6.4% and 20% juice) in healthy adults (N=32) who typically consumed low amounts of fruits and vegetables.Ray 2016 In contrast, a study examining the effects of black currant on exercise-induced muscle damage demonstrated that the significantly decreased plasma antioxidant activity postexercise in untrained participants was mitigated in the group consuming black currant nectar (32 ounces/day [containing 200 g/day of fruit]) for 8 days (P=0.039 compared to placebo).Hutchinson 2016, In one study, supplementation with black currant seed oil in both mothers and 12-month-old infants resulted in a significant reduction in the prevalence of atopic dermatitis.Foolad 2013 The cytokines in breast milk and their associations with black currant seed oil supplementation, mother's atopic status, and development of infant atopic dermatitis were assessed in 61 mothers and their infants chosen from the study population of a double-blind, randomized, placebo-controlled trial. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. This includes: • Vitamin C • Vitamin B1 • Vitamin B5 • Vitamin B6 • Iron • Manganese • Vitamin E. There are many great benefits of taking black currant seed oil: J.Hum.Hypertens. Eur J Clin Nutr 2003;57:37-42. However, no changes were observed in metabolites of nitric oxide, advanced oxidative protein products, and serum antioxidant activity.Yoshida 2013, Limited clinical trial data exist to provide dosage recommendations. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. Additionally, IL-10 levels in breast milk were significantly lower at 3 months in mothers who had atopic dermatitis (P=0.044).Linnamaa 2013, Black currant juice 300 mL/day for 5 days did not have acute effects on lipid parameters, the potent vasoconstrictor endothelin-1, hemostatic factors (ie, tissue plasminogen activator antigen [TPA-Ag], plasminogen activator inhibitor antigen [PAI-Ag]), or the inflammatory biomarker C-reactive protein in healthy male seminarians who were nonsmokers and lifelong abstainers from alcohol. How do I take it? This product may be unsafe when used before surgery or other medical procedures. No effects on blood pressure and pulse were noted.Ohguro 2013 In order to explore mechanisms of black currant anthocyanins in glaucomatous optic neuropathy, blood samples from the 38 patients who completed the initial trial were used to determine the effects of black currant anthocyanins on serum biomarkers regulating vessel contraction and antioxidative stress. For evening primrose oil capsules with maximum potency, to get the same amount of GLA the math works out to be 3,400 mg of the oil. In the early 1900s, black currant farming was banned in the United States because the plant was considered to be a vector for fungi that caused white pine blister rust, which threatened the logging industry. The plant grows to an untrimmed height of about 1.2 to 2.1 m and has tooth-edged, maple-like leaves.Gopalan 2012 The fruits are resistant to cold or changing temperatures but do not thrive in hot or dry climates. View abstract. One study published in 2005 in the "Journal of Nutritional Biochemistry" found that black currant seed oil was able to lower bad cholesterol levels more than a fish oil supplement. Black currant is a stout, woody, usually spineless, deciduous shrub native to northern Asia and central and eastern Europe and cultivated in the United States and throughout the world. In spring, the flowers are yellowish-white, are shaped like small bells, and grow alternately in a row. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. High blood pressure. Ribes nigrum, the blackcurrant, is a medium-sized shrub, growing to 1.5 by 1.5 metres (5 by 5 ft).The leaves are alternate, simple, 3 to 5 cm (1 1 ⁄ 4 to 2 in) broad and long with five palmate lobes and a serrated margin.All parts of the plant are strongly aromatic. Black currant anthocyanins 50 mg/day was associated with a reduction in intraocular pressure at 2 and 4 weeks, as well as after 24 months of treatment. Safety and Dosage Because black currant seed oil may have antibacterial activity, be cautious when combining it with antibiotics or ulcer medications. The essential fatty acids found in GLA 90 Black Current Oil help maintain moisture in the eyes and skin, and Omega-6 may play a role in mediating collagen production in the skin. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. View abstract. Suzutani, T., Ogasawara, M., Yoshida, I., Azuma, M., and Knox, Y. M. Anti-herpesvirus activity of an extract of Ribes nigrum L. Phytother.Res. At this time there is not enough scientific information to determine an … Its biological name is Ribes nigrum. Black currant is a plant. J Agric Food Chem. How it might affect other drugs hasn’t been well studied and no trials have been done to find the best dosage of blackcurrant seed oil for musculoskeletal conditions, although trials have used doses of 3 g … View abstract. Some Ribes species are fragrant, but R. nigrum possesses a strong, unpleasant odor. Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans. Information regarding safety and efficacy in pregnancy and lactation is lacking. People use the seed oil, leaves, fruit, and flowers to make medicine. The essential fatty acids (EFA’s) in black currant seed oil could also regulate metabolism, improve imbalances in the blood like blood pressure, cholesterol, and sugar levels. Röhrig T, Kirsch V, Schipp D, Galan J, Richling E. Absorption of anthocyanin rutinosides after consumption of a blackcurrant (Ribes nigrum L.) extract. Dejima K, Ohshima A, Yanai T, et al. Ohguru H, Ohguru I, Katai M, Tanaka S. Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma. View abstract. Painful menstrual periods (dysmenorrhea). View abstract. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Dosage for Black Seed Oil Capsules Not everyone is ready to accept the taste of black seed oil. View abstract. In the fall, clusters of 4 to 6 black-red fruits ripen from the main branch and are used to make jams and jellies.van Wyk 2005 Ribes species in the Grossulariaceae (currant) family are sometimes included in the Saxifragaceae family.Määttä 2003, USDA 2013. J Nutr Biochem 2005;16:353-9. The oil reduces treat the pain and swelling of joints caused by arthritis. Does it really work though? Mutat.Res. 2018;10(4). So you bought your first bottle of Black Seed Oil…now what? That works out to be around 1,700 mg of the pure oil. Oil and juice extracts have also exhibited limited antimicrobial and prebiotic activities, as well as potential benefit in preventing infant atopic dermatitis, reducing cardiovascular risk, and improving certain exercise performance measures. It makes up 14% of the total amount of fatty acids. J Biochem Biophys Methods 2002;53(1-3):61-66. Black currant seed oil contains a lot of nutrients, especially vitamins. J Clin Immunol 2002;22:83-91. Its leaves have been used to treat diarrhea very effectively. View abstract. For black currant oil supplements, an even higher dosage is used to obtain the equivalent amount of GLA. Black currant oil is extracted from the seeds of black currants. Borage seed oil 1 to 3 g/day has been given in clinical trials (1 g/day has been used in children and up to 3 g/day has been used in adults).44, 53, 78 The content of GLA is 20% and 26% of the oil.48, 49 A 2 g dose of dried herb brewed in 1 cup of boiling water taken 3 times daily has been suggested.79 Oral doses of 2,000 to 4,000 mg/day (GLA 400 to 1,000 mg) in adults and 1,000 to 2,000 mg/day (GLA 240 to 480 mg) in children with atopic dermatitis have been studied.61 Urinary excretion and effects on biological markers for antioxidative status]. 0:16 Benefits of black currant seed oil 1:05 Why you need this black currant oil antioxidant. View abstract. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Matsumoto, H., Nakamura, Y., Hirayama, M., Yoshiki, Y., and Okubo, K. Antioxidant activity of black currant anthocyanin aglycons and their glycosides measured by chemiluminescence in a neutral pH region and in human plasma. Compared with baseline, population sizes of gut microbes associated with improved health, specifically Lactobacillus and Bifidobacterium species, increased significantly (P<0.0001), whereas those associated with poor health, specifically Clostridium and Bacteroides species, decreased significantly (P<0.0001). Phlebologie. Black currant oil and extracts can reduce the risk factors for metabolic conditions which include diabetes; both type 1 and type 2. 1992;45(2):167-173. Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice. Additionally, plasma antioxidant capacity was maintained at 48 hours postexercise with consumption of black currant nectar, compared with significant decreases in the placebo group (P=0.039).Hutchinson 2016, Black currant inhibited alpha-glucosidase, with effects similar to those of acarbose, suggesting potential dietary use for glycemic control in type 2 diabetes.Boath 2012, In a randomized, controlled, crossover study of 20 healthy women, consumption of black currants or lingonberries was associated with an improvement in glycemic profile; specifically a reduced late postprandial hypoglycemic response was observed.Törrönen 2012, The 2012 American College of Rheumatology guidelines on the management of gout state that the use of various oral complementary agents, including black currant, is inappropriate for the treatment of an acute gout attack.Khanna 2012, In a study evaluating the effects of black currant on the immune response of healthy elderly subjects, a dosage of six 750 mg capsules daily (4.5 g/day) of black currant seed oil (as a source of gamma-linolenic acid) did not adversely affect immune response and may have a moderate immunoenhancing effect due, in part, to its reduction of prostaglandin E2 production.Wu 1999, In vitro and animal studies evaluating the effects of black currant extracts and anthocyanins on lipid profiles produced varying (both positive and negative) results on cholesterol and triglycerides.Barre 2001, Finné Nielsen 2005, Frank 2002. According to Healthline, black currant is likely safe when taken at doses of 1000 milligrams per day. Its biological name is Ribes nigrum. View abstract. Dosing considerations for Black Currant. Black currant oil and extracts can reduce the risk factors for metabolic conditions which include diabetes; both type 1 and type 2. Its leaves have been used to treat diarrhea very effectively. Agostoni, C., Riva, E., Biasucci, G., Luotti, D., Bruzzese, M. G., Marangoni, F., and Giovannini, M. The effects of n-3 and n-6 polyunsaturated fatty acids on plasma lipids and fatty acids of treated phenylketonuric children. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Compared with placebo, patients receiving the anthocyanins experienced an increase in serum endothelin-1 to levels comparable with healthy controls. (3, 4) Even hormonal imbalances affecting the thyroid and menopause may be balanced out by taking black currant seed oil in the right dosage over a period of 1 – 6 months. Lengsfeld, C., Deters, A., Faller, G., and Hensel, A. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. The appropriate dose of black currant for use as treatment depends on several factors such as the user's age, health, and several other conditions. Black current plant was first domesticated for its fruit approximately 400 to 500 years ago. Gopalan A, Reuben SC, Ahmed S, et al. Available at: https://home.intekom.com/pharm/searle/epogm.html. In a few small, double-blind, randomized, placebo-controlled crossover trials conducted in athletes (study sizes ranging from 13 to 14 participants), benefit in some performance measures was demonstrated with short-term (7-day) consumption of New Zealand black currant extract.Cook 2015, Perkins 2015, Willems 2015 Compared with placebo, New Zealand black currant extract 300 mg/day (CurraNZ; containing 105 mg/day of anthocyanins) was associated with a significant increase in mean number of sprints (from 32 to 35; P=0.02) and total distance covered (10% greater with extract vs placebo; P=0.023),Perkins 2015 as well as in mean cycling completion time (P=0.027).Cook 2015 However, results regarding black currant's effects on physiological parameters have been equivocal; no interaction effect on physiological response, perceptual response, or recovery was found with 300 mg/day,Perkins 2015 whereas improvements in fat oxidation, lactate response, and resting cardiovascular function (ie, stroke volume, cardiac output) were observed in other studies using New Zealand black currant extracts (CurraNZ 300 mg/day or Sujon [black currant powder containing 138.6 mg of anthocyanin] 6 g/day dissolved in water).Cook 2015, Willems 2015 None of these studies demonstrated an interaction effect on cardiovascular function during performance. In a clinical trial assessing effects of dietary intake of a black currant juice drink on oxidative stress and vascular function in healthy subjects, no effects on cholesterol and triglycerides were observed.Khan 2014 In another study in 15 healthy females, black currant seed oil produced positive effects on plasma lipids.Tahvonen 2005 Links with positive cardiovascular effects have not been established. A tea made from 2 to 4 g of chopped leaves can be administered several times per day. View abstract. Tea made from 2 to 4 g of chopped leaves can be administered several times per day.van Wyk 2005, Black currant juice 300 mL/day for 5 days was used in a study evaluating the effects of various beverages on several cardiovascular disease risk parameters.Banach 2013 In a study of healthy volunteers to assess the effects of dietary intake of black currant juice on oxidative stress and vascular function, 250 mL/day of low-concentration (6.4%) or high-concentration (20%) black currant juice drink was administered for 6 weeks.Khan 2014 In another study, New Zealand black currant extract (CurraNZ; containing 105 mg of anthocyanin) was administered at doses of 300, 600, and 900 mg/day to endurance-trained males to evaluate effects on cardiovascular function/cardiovascular risk (mean arterial pressure, cardiac output, stroke volume, and total peripheral resistance).Cook 2017, 32 oz/day of black current nectar (approximately 946 mL/day, containing 200 g/day of fruit) for 8 days was administered to evaluate its effects on exercise-induced muscle damage (ie, inflammatory status, oxidative stress).Hutchinson 2016, In short-term studies investigating effects on exercise performance and recovery, A New Zealand black currant extract (CurraNZ; containing 105 mg of anthocyanin) has been dosed at 300 mg/day for 7 days,Cook 2015, Perkins 2015 while another New Zealand black currant powder (Sujon; containing 138.6 mg of anthocyanin) dissolved in water has been administered at a dosage of 6 g/day for 7 days.Willems 2015, A dosage of six 750 mg capsules daily (4.5 g/day) of black currant seed oil (as a source of gamma-linolenic acid) was used to evaluate effects on immune response of healthy elderly subjects.Wu 1999, Black currant extract powder (Cassis Anthomix 30) 672 mg/day for 2 weeks has been used to promote growth of beneficial bacteria.Molan 2014, Black currant seed oil equivalent to gamma-linolenic acid 525 mg was used for 6 weeks in one rheumatoid arthritis trial,Watson 1993 and 10.5 g of oil daily for 24 weeks was used in another trial.Leventhal 1994, 330 mL of black currant juice was administered daily in a small trial investigating the effects on urolithiasis risk factors.Kessler 2002, Because gamma-linolenic acid decreased platelet aggregation and increased bleeding times in rats fed evening primrose oil, theoretically an interaction between black currant oil and anticoagulants such as warfarin is possible.Norred 2001 Other in vitro studies add to this consideration.Barre 2001, Pregnolato 1996, Black currant ingestion was associated with an oral allergy syndrome in a patient with allergy to grass pollen. 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